George O'Brien
George O'Brien may refer to:
- George O'Brien (writer) (born 1945), Irish academic and writer of short fiction and memoir
- George O'Brien (actor) (1899–1985), American silent movie actor
- George O'Brien (baseball) (1889–1966), American baseball player
- George O'Brien (cricketer) (born 1984), Bermudian cricketer
- George O'Brien (economist) (1892–1973), Irish economist
- George O'Brien (footballer) (born 1935), former Southampton F.C. footballer
- George O'Brien (1900s footballer), English footballer
- George O'Brien (painter) (1821–1888), New Zealand painter
- G. Dennis O'Brien (born 1931), former president of the University of Rochester
- George D. O'Brien (1900–1957), U.S. Representative from Michigan
- George H. O'Brien, Jr. (1926–2005), Korean War Congressional Medal of Honor recipient
- George M. O'Brien (1917–1986), U.S. Representative from Illinois
- George Thomas Michael O'Brien, former governor of Fiji
- George O'Brien, a fictional politician, based on Walter A. O'Brien, in the Kingston Trio song "M.T.A."